Tremors were felt over the locale, with further death toll in India, Bangladesh, Tibet and on Mount Everest.
The legislature has pronounced a highly sensitive situation in the influenced regions.
A national police representative told the BBC that 970 individuals had kicked the bucket in the shudder, and that more than 1,700 had been harmed. No less than 539 individuals were murdered in the Kathmandu valley, he included.
Nepali Information Minister Minendra Rijal said there had been "monstrous harm" at the epicenter, from where little data is rising.
Get the most recent reports on the Nepalese quake
"We need backing from the different global offices which are more educated and prepared to handle the sort of crisis we confront now," he said.
The US is sending a debacle reaction group to Nepal and has discharged an introductory $1m (£0.7m) to address prompt needs, the US help office USAid has said.
Various noteworthy structures have been crushed.
Among those destroyed was the milestone Dharahara tower, with numerous dreaded caught in its demolishes.
After the tremor struck, terrified inhabitants turned out into the roads. Cell telephones and different interchanges have been disturbed.
Major notable landmarks in the Nepalese capital have been obliterated in the effective quake, onlookers and authorities have said.
These incorporate a nine-story tower, sanctuaries and a few sections of what was previously an illustrious royal residence, all recorded as Unesco world legacy destinations.
Pictures posted on online networking demonstrate a percentage of the landmarks have been lessened to rubble.
Observers say a few others now have splits and could crumple.
Authorities have said a few sanctuaries and landmarks at other world legacy destinations close Kathmandu have likewise been harmed.
These locales are Nepal's significant vacation destinations.
Nepal had lost a few such landmarks amid a real seismic tremor in 1934.
Tremor levels Nepal historic points
There are likewise reports of harm to Kathmandu air terminal which could hamper help operations.
With minimal thought about the degree of the harm around the tremor's epicenter, there are reasons for alarm the loss of life could rise.
Post-quake tremors kept on undulating through the district hours after the fact.
The shake set off a torrential slide on Mount Everest, slaughtering no less than eight individuals, and another five in Tibet, authorities and reports say.
"Running for life from my tent. Unhurt. Numerous individuals up the mountain," tweeted mountain dweller Alex Gavan.
World's deadliest late tremors
Iran, 2003: More than 26,000 individuals slaughtered in 6.6 tremor close to the city of Bam
Indonesia, 2004: Devastating 9.1 tremor and following tidal wave off the Sumatran region of Aceh slaughters more than 230,000 individuals in twelve nations
Pakistani-directed Kashmir, 2005: 7.6 tremor close Muzafferabad slaughters around 100,000 individuals
China, 2008: Nearly 90,000 slaughtered in 7.9 tremor in eastern Sichuan territory
Haiti, 2010: More than 220,000 individuals slaughtered in 7.0 size tremor
No less than 35 individuals have been slaughtered in India, Indian authorities say, with one demise additionally reported in Bangladesh.
Indian Prime Minister Narendra Modi has met his clergymen to audit the circumstance. Pakistan's Prime Minister, Nawaz Sharif, has promised help for the Nepalese powers.
It is the most exceedingly bad seismic tremor to strike Nepal since one in 1934 everything except demolished Kathmandu.
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